Wed Oct 29 09:45:37 UTC 2025: NEWS ARTICLE:

India Focuses on Huntington’s Disease: Researchers, Clinicians, and Patients Unite

Bengaluru, India – October 29, 2025 – The Huntington’s Disease Society of India (HDSI) recently convened its second annual meeting at NIMHANS, Bengaluru, uniting patients, caregivers, researchers, and clinicians to address the complexities of Huntington’s Disease (HD). The gathering highlighted progress in understanding and managing this debilitating neurodegenerative disorder, with a strong emphasis on the importance of collaboration between scientists and patients.

HD is a genetic disease characterized by motor deficits, cognitive difficulties, and psychiatric challenges. Caused by a mutation in the Huntingtin gene, symptoms typically emerge in adulthood and progressively worsen. Experts estimate that between 20,000 to 40,000 individuals in India suffer from HD, with a potentially much larger at-risk population.

Indian researchers are making significant strides in understanding HD mechanisms. The fruit fly (Drosophila melanogaster) has emerged as a valuable model for studying the disease, allowing scientists to track disease progression at the molecular, cellular, behavioral, and systemic levels. Researchers are using this model to investigate potential treatments.

Beyond laboratory research, therapeutic approaches are also being explored. Studies suggest that dance therapies, such as Argentine tango and contemporary dance, can help patients manage movement disturbances and improve mood. Dancer Daksha Mashruwala proposed a choreographic therapy for HD patients using Odissi, an Indian classical dance form, to help counter uncontrolled movements.

Despite advancements, challenges remain. A key obstacle is the lack of a patient registry, which would facilitate enrollment in clinical trials, expand doctor networks, and raise awareness about HD. Concerns over anonymity and social stigma continue to hinder registration efforts.

The meeting underscores the need for continued research, improved patient care, and greater awareness of HD in India. The collaborative spirit among researchers, clinicians, and patients offers hope for future advancements in managing this devastating disease.

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