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News Article: Mystery Kidney Disease Emerges as Threat to Young Adults in Telangana

Hyderabad, October 26, 2025: A new study reveals that chronic kidney disease of unknown origin (CKDu) is increasingly affecting younger, economically active individuals in Telangana, including Hyderabad, posing a significant health challenge. The research, published in the Indian Journal of Nephrology, highlights the emergence of CKDu in patients without typical risk factors like diabetes or hypertension.

The study, conducted by nephrologists from Osmania General Hospital (OGH) and Apollo Hospitals, examined 75 patients between March 2021 and November 2022. The average age of participants was 41.7 years, with 68% being male. A significant portion (77.3%) relied on groundwater as their primary drinking source. Furthermore, 40% had used alternative medicine, and 46.6% underwent kidney biopsies.

Histological analysis of kidney tissue revealed widespread damage, including glomerulosclerosis (54%), interstitial fibrosis and tubular atrophy (31%), and periglomerular fibrosis (34.3%). Interstitial inflammation was observed in 85.7% of the samples.

“Our findings confirm that CKD patients meeting the CKDu criteria are present in Telangana, even outside traditional agricultural hotspots,” explained Dr. Manisha Sahay, Head of Nephrology at Osmania General Hospital. “This is the first documented report of its kind in the region.”

The study also noted that 69% of patients were still producing normal amounts of urine despite kidney problems, while 28% experienced frequent nighttime urination. The majority reported fatigue or weakness, and swelling was observed in some cases. Most participants were from Hyderabad (42.7%) and Rangareddy district (10%). A third (33%) had high uric acid levels, and 40% were already in the most severe stage of kidney disease, with some requiring dialysis at the time of diagnosis.

The research underscores the need for further investigation into the causes of CKDu in Telangana, particularly focusing on potential environmental factors and lifestyle influences. Public health initiatives aimed at promoting safe drinking water and early detection of kidney problems are crucial to address this emerging threat.

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