Mon Sep 16 15:13:33 UTC 2024: ## NIH Funds Research on 3D Cellular Models to Advance HIV Cure Efforts
**Bethesda, MD** – The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) has announced a new funding opportunity for research focused on developing and utilizing three-dimensional (3D) cellular models to advance HIV research. This initiative aims to overcome limitations of traditional 2D cell culture models and nonhuman primate studies, paving the way for more accurate and insightful research on HIV persistence, latency, reactivation, eradication, and associated comorbidities.
The NOFO seeks to support projects that utilize innovative 3D models such as microphysiological systems and organoids to explore HIV interactions with tissues and processes relevant to NIDDK’s mission. This includes investigating the virus’s impact on the gastrointestinal mucosa, genital tract, kidney, and adipose tissue, all of which can serve as HIV reservoirs.
“Traditional research methods haven’t fully captured the complex interactions within the human body that influence HIV,” said Dr. John Connaughton, Chief of the Scientific Review Branch at NIDDK. “These 3D models offer a powerful tool to study the intricate interplay of organ systems, immune responses, and inflammatory pathways, leading to a deeper understanding of HIV dynamics.”
The NOFO specifically invites applications focusing on developing a cure for HIV and understanding HIV-associated comorbidities, co-infections, and complications. These include conditions like enteropathy, liver diseases, kidney diseases, and metabolic disorders.
The Office of Research on Women’s Health (ORWH) is also co-funding projects with a focus on the female genital tract, emphasizing organ-on-a-chip models of the cervico-vaginal mucosa and the female reproductive system.
The NIDDK intends to commit $3,000,000 in FY 2026 to fund up to four awards. The maximum budget per award is $500,000 per year, with a maximum project period of five years.
“This initiative is crucial for accelerating HIV research and ultimately finding a cure,” said Dr. Elizabeth Anne Barr of the ORWH. “By supporting projects that explore the intricate relationships between HIV and various organ systems using advanced cellular models, we are creating a path for groundbreaking discoveries and better treatments.”
Applications are due by 5:00 PM local time of the applicant organization, and applicants are encouraged to apply early to allow for any necessary corrections. For more information on eligibility, submission requirements, and contact details, visit the NIH Grants & Funding website.
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