– Novak Djokovic lost in four sets to 28th seed Alexei Popyrin in the US Open third round
– Djokovic will finish the year without a Grand Slam title for the first time since 2017
– This is the first time since 1973 that the second and third seeds have been ousted before the fourth round in men’s singles at the US Open
– Djokovic made a comeback in the third set but ultimately lost the match
– Popyrin will face American Frances Tiafoe in the fourth round
– Jannik Sinner, the world No. 1, has a chance to win his first Grand Slam title at the US Open.