Sun Dec 28 18:50:00 UTC 2025: NFL Week 17: Expert Picks and Upset Alerts

[City, State] – After a Christmas Day slate dominated by underdog performances, NFL fans are wondering if Week 17 will bring more of the same. CBS Sports analysts are highlighting several games with upset potential, offering their best bets and predictions for the remaining matchups.

One game to watch is the Philadelphia Eagles (10-5) at the Buffalo Bills (9-6). Despite being slight underdogs (+1.5), the Eagles are projected to win 27-24, fueled by a resurgent Saquon Barkley facing a struggling Bills run defense, and an improved Jalen Hurts.

Another potential upset lies in the Tennessee Titans (5-10) at the New Orleans Saints (7-8) game, where the Titans are +2.5 underdogs. The Titans’ Cam Ward is on a breakout streak, while the Saints’ offense is struggling with injuries, creating a favorable matchup for Tennessee. Projected score: Titans 23, Saints 21.

The analysts are also high on the Cincinnati Bengals (8-7), who are favored by -7.5 against the Arizona Cardinals (3-12). With their offense firing on all cylinders, the Bengals are expected to continue their strong performance. Projected score: Bengals 33, Cardinals 23.

Other games highlighted include the Jacksonville Jaguars (8-7) at the Indianapolis Colts (8-7), with the Jaguars favored by -5.5. Analysts believe Trevor Lawrence’s stellar play will lead Jacksonville to victory. Projected score: Jaguars 27, Colts 20.

Here’s a quick rundown of the remaining picks:

  • Texans at Chargers: Texans +1.5 (Projected: Texans 23, Chargers 21)
  • Ravens at Packers: Packers -4.5 (Projected: Packers 24, Ravens 17)
  • Patriots at Jets: Patriots -13.5 (Projected: Patriots 30, Jets 16)
  • Steelers at Browns: Browns +3 (Projected: Steelers 21, Browns 20)
  • Seahawks at Panthers: Panthers +7 (Projected: Seahawks 27, Panthers 21)
  • Buccaneers at Dolphins: Buccaneers -5.5 (Projected: Buccaneers 27, Dolphins 20)
  • Giants at Raiders: Raiders +1.5 (Projected: Raiders 23, Giants 17)
  • Bears at 49ers: 49ers -3 (Projected: 49ers 30, Bears 24)
  • Rams at Falcons: Rams -7.5 (Projected: Rams 30, Falcons 20)

Disclaimer: This content is for entertainment purposes only. CBS Sports makes no guarantees regarding the accuracy of these predictions. Odds are subject to change.

Source: DraftKings Sportsbook

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