Tue Oct 07 03:20:00 UTC 2025: **FOR IMMEDIATE RELEASE**

**NFL Week 5 Sees Upsets Galore; Week 6 Odds Released**

**[City, State] – October 16, 2025** – Week 5 of the 2025-26 NFL season delivered a shocking dose of upsets, leaving many bettors reeling. The Arizona Cardinals, favored by 7.5 points, suffered a stunning 22-21 loss to the Tennessee Titans, eliminating many from survivor pools. The Buffalo Bills, an 8-point favorite, also fell at home to the New England Patriots in a 23-20 Sunday Night Football showdown.

Despite the week’s surprising outcomes, attention has already shifted to Week 6, with BetMGM releasing the opening betting lines for all matchups. Key games to watch include the Philadelphia Eagles visiting the New York Giants (-7), the Denver Broncos taking on the New York Jets (-7.5) in London, and the Cincinnati Bengals facing a hefty 14.5-point underdog status against the Green Bay Packers.

Here’s a quick rundown of the early Week 6 odds:

* Philadelphia Eagles (-7, 41.5) at New York Giants
* Denver Broncos (-7.5, 43.5) at New York Jets (London)
* Cleveland Browns at Pittsburgh Steelers (-5, 37.5)
* Arizona Cardinals at Indianapolis Colts (-5.5, 47.5)
* Los Angeles Chargers (-5.5, 44.5) at Miami Dolphins
* New England Patriots (-3.5, 46) at New Orleans Saints
* Dallas Cowboys (-3.5, 49) at Carolina Panthers
* Seattle Seahawks at Jacksonville Jaguars (-1, 45.5)
* Los Angeles Rams (-7.5, 45.5) at Baltimore Ravens
* Tennessee Titans at Las Vegas Raiders (-6, 41.5)
* Cincinnati Bengals at Green Bay Packers (-14.5, 44.5)
* San Francisco 49ers at Tampa Bay Buccaneers (-2.5, 47.5)
* Detroit Lions at Kansas City Chiefs (-1.5, 49.5)
* Buffalo Bills (-4, 49.5) at Atlanta Falcons
* Chicago Bears at Washington Commanders (-4, 50.5)

The Minnesota Vikings and Houston Texans will enjoy a bye in Week 6.

As always, these odds are subject to change leading up to kickoff. Be sure to stay updated on injury reports, weather forecasts, and all other factors that could influence these games.

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