Fri Sep 12 08:50:00 UTC 2025: **Summary:**

The Colorado Buffaloes are set to face the Houston Cougars in a Week 3 college football game on September 12th at TDECU Stadium in Houston. Despite Houston being favored by 4.5 points according to BetMGM, predictions are mixed. One model gives Houston a 63% win probability, while another suggests Colorado will pull off the upset, even with key players like Shedeur Sanders and Travis Hunter potentially absent. The game will be broadcast on ESPN at 4:30 p.m. MST.

**News Article:**

**Buffaloes Face Cougars in Week 3 Showdown: Upset Brewing?**

**HOUSTON, TX** – The Colorado Buffaloes head to Houston to take on the Cougars on Friday, September 12th, in a highly anticipated Week 3 college football matchup. The game, set to kick off at 4:30 p.m. MST and broadcast on ESPN, marks a crucial early test for both Big 12 Conference teams.

Houston enters the game as a 4.5-point favorite, according to BetMGM Sportsbook. However, predictions for the game are far from certain. While one predictive model gives Houston a 63% chance of victory, others suggest the Buffaloes could defy the odds.

Adding to the intrigue, questions loom over the availability of key Colorado players, including star quarterback Shedeur Sanders and two-way phenom Travis Hunter. One analysis from azcentral.com suggests that even without these key players, the Buffaloes “still have some firepower, particularly on offense.”

Despite Houston’s favoratism, predictions suggest that Colorado will “find enough holes in Houston’s defense to grab the road win.” The game promises to be a battle, with national interest piqued as Coach Prime’s Buffaloes seek to continue their program rebuild.

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