Thu May 08 16:24:44 UTC 2025: **Chennai Scientists Discover New Diabetes Subtype, Advocate for Wider Genetic Testing**

**CHENNAI, INDIA (May 8, 2025)** – Scientists at the Madras Diabetes Research Foundation (MDRF) in Chennai, in collaboration with Washington University School of Medicine, have identified a previously unknown subtype of Maturity-Onset Diabetes of the Young (MODY). This discovery, published in the journal *Diabetes*, highlights the urgent need for increased access to genetic screening and personalized diabetes treatments, particularly in India.

MODY is a rare, inherited form of diabetes. While 13 subtypes were previously known, this newly identified variant, caused by Loss of Function (LOF) mutations in the ABCC8 gene, presents differently. Unlike previously identified MODY subtypes, it initially causes hypoglycemia (low blood sugar) in early life, later progressing to diabetes. This progression was previously undocumented.

The research team, led by Dr. Colin G. Nichols of Washington University and Dr. Radha Venkatesan of MDRF, found that the LOF mutation disrupts insulin secretion by impairing potassium channel function in pancreatic beta cells. This contrasts with previously identified MODY subtypes linked to Gain of Function (GOF) mutations. Critically, this new variant does not respond to standard treatments like sulfonylureas, emphasizing the need for tailored therapies based on genetic understanding.

Dr. V. Mohan, chairman of MDRF, stressed the significance of integrating genetic testing into routine diabetes diagnosis. He noted that many individuals with MODY remain undiagnosed or misdiagnosed with type 1 or type 2 diabetes. The study’s findings, based on data from Indian patients, underscore the potential for earlier detection and improved management through expanded access to genetic testing. The researchers believe this could significantly improve the lives of thousands with undetected or misclassified forms of monogenic diabetes.

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