Tue Apr 29 15:30:00 UTC 2025: ## Madrid Open Upset Predictions: Berrettini, Musetti Favored Against Odds

**Madrid, Spain** – The second week of the Mutua Madrid Open is underway, but unexpected power outages earlier in the week caused significant disruptions. Despite the setbacks, several intriguing Round of 16 matches are set to captivate tennis fans. While betting odds favor certain players, expert analysis suggests some potential upsets.

**Draper vs. Berrettini (28.04.2025, 18:00 CEST):** Bookmakers predict a Jack Draper victory, but analysts disagree. While Draper has a 2-0 head-to-head advantage and won his opening match against Griekspoor, his struggles on clay are a concern. Berrettini, conversely, thrives on clay and his three-set win over Giron demonstrates his current form. The prediction is a tight match, with Berrettini potentially covering the games handicap (+2.5 games @ 1.80 odds).

**Tsitsipas vs. Musetti (28.04.2025, 20:00 CEST):** This 50/50 matchup according to the bookies, is seen differently by experts. Musetti’s strong recent form, including a runner-up finish in Monte Carlo and a straight-sets victory over Etcheverry in Madrid, makes him a strong contender. His previous win over Tsitsipas in Monte Carlo further bolsters his chances. Musetti’s victory is considered a value bet (@ 1.91 odds).

**De Minaur vs. Shapovalov (28.04.2025, 20:30 CEST):** Both analysts and bookmakers favor Alex de Minaur in this match. De Minaur’s strong performance on clay, his recent straight-sets victory over Sonego, and experience playing in Spain contribute to this prediction. A straight-sets win for de Minaur (@ 1.73 odds) is considered a valuable bet.

The article was cut off before a full preview of all matches. The remainder of the preview (including the Tiafoe-Muller match) will be included in a follow-up report.

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