Wed Apr 09 14:03:54 UTC 2025: ## Anti-Aging Millionaire Rejects Rapamycin After Unexpected Side Effects
**San Francisco, CA** – Tech entrepreneur Bryan Johnson, known for his ambitious anti-aging regimen, has publicly abandoned rapamycin, a drug he previously considered central to his health optimization plan. In a recent YouTube video, Johnson detailed a series of concerning side effects experienced while taking the immunosuppressant, including mouth ulcers, delayed wound healing, elevated cholesterol, and increased resting heart rate.
Johnson, who had been using rapamycin for five years based on promising studies in mice and initial human trials, stated that the drug ultimately proved counterproductive to his goals. His decision was further influenced by a recent Yale University study that suggested rapamycin might actually accelerate biological aging by negatively impacting epigenetic markers.
While acknowledging the irony of his situation with characteristic humility (“To those of you laughing at home, I’m laughing with you,” he stated in the video), Johnson emphasized that this is not a failure, but a necessary recalibration of his approach. He has ceased rapamycin use and intends to continue his quest for longevity through adjusted strategies. The video concludes with Johnson emphasizing the importance of transparency in health experimentation, highlighting the value of sharing both successes and setbacks in the pursuit of scientific progress.
First Piper 