Wed Jan 29 07:52:28 IST 2025: ## Pune Battles Largest-Ever Guillain-Barré Syndrome Outbreak Linked to Bacterial Infection

**PUNE, INDIA (January 29, 2025)** – A significant outbreak of Guillain-Barré Syndrome (GBS) in Pune, India, has been linked to a bacterial infection, prompting a major public health response. Over 100 suspected cases have been reported, with one death. Investigations reveal *Campylobacter jejuni*, a bacteria found in contaminated food and water, as the culprit behind the initial cluster. Almost all patients experienced gastroenteritis symptoms (vomiting, diarrhea, nausea) before developing the characteristic GBS symptoms of peripheral numbness and paralysis.

This outbreak highlights vulnerabilities in Pune’s infrastructure, with pathogens breaching safety nets and causing widespread illness. The sheer number of cases suggests it may be the largest GBS outbreak in India’s recorded history, though large-scale epidemiological studies on GBS in India are lacking. Globally, GBS affects 1-2 per 100,000 people, predominantly adult males.

GBS, a rare autoimmune disorder, attacks the peripheral nervous system. While most patients recover with plasma exchange or intravenous immunoglobulin therapy, early treatment within two weeks of symptom onset is crucial. Rapid response teams are collecting water samples and conducting community surveillance, while a central team has been deployed to affected areas.

Authorities are emphasizing the need for swift patient identification and treatment initiation. They are also stressing the importance of providing clean drinking water and public health messaging on food safety to prevent further spread. The outbreak underscores the need for improved sanitation and surveillance systems to prevent future outbreaks.

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