Sat Dec 07 18:29:00 UTC 2024: **Spike Protein Linked to Long COVID Brain Inflammation: Study**
CHENNAI, India (December 8, 2024) – New research suggests a persistent presence of the COVID-19 spike protein in the brain may be a key driver of Long COVID’s neurological symptoms. Two recent studies, published in *Cell Host & Microbe* and *Brain, Behavior, and Immunity – Health*, offer insights into how the virus, even after clearance, can trigger long-term inflammation and damage.
One study found that injecting spike protein into the skulls of mice caused brain inflammation and behavioral changes. Importantly, this effect wasn’t observed in vaccinated mice, suggesting that the immune response to the virus itself, and not the vaccine, is the culprit. Researchers also detected spike protein in the skulls of humans who died from causes unrelated to COVID-19, highlighting its lingering presence. This persistent spike protein correlates with elevated levels of biomarkers indicating brain cell damage in Long COVID patients.
The second study focused on the role of microglia, the brain’s immune cells. These cells, when activated by the virus, can trigger prolonged inflammation, potentially leading to cognitive impairments. Other potential pathways, such as the virus accessing the brain through the olfactory nerve or breaching the blood-brain barrier, are also under investigation.
Dr. Rajeev Jayadevan, co-chairman of the National IMA COVID task force, emphasizes that while the studies shed light on the mechanisms behind Long COVID, there is currently no definitive cure. The challenge lies in developing effective treatments that target these complex pathways without harming the body. Further research is crucial to developing therapies that can alleviate symptoms and improve the quality of life for those affected by Long COVID.
First Piper 